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Why Are Cells the Size They Are?

Organisers: Dustin Marshall and Craig White

Date: 13 – 16 July 2025

Location: Buxted Park, East Sussex, UK

Size determines function – larger organisms are very different to smaller organisms. Understanding size-function relationships is a longstanding goal of biology (Thompson, 1917). This problem has taken on new urgency because, across the tree of life, organisms are shrinking in response to human-mediated change. Across a broad swathe of organisms and particularly unicells, global warming and shifts in nutrient regimes are inducing size declines (Forster, Hirst & Atkinson, 2012; Hillebrand et al., 2022).  What are the consequences of these changes in size? How do they affect biological function, which in turn drive the ecosystem services we rely upon?

We believe a new synthesis is required for understanding how and why cell size varies, as well as the functional consequences of changes in cell size. From cell biologists to biogeophysicists, there is a strong, unifying interest in understanding cell size and its dynamics but these very different fields have barely overlapped in the past. We propose to bring together a diverse group with very different skillsets and expertise to tackle this urgent problem of understanding cell size.

Our goal is to create a new theory base, that integrates the latest advances in biophysics, evolutionary biology and ecological modelling in order to better understand cell size. We anticipate a series of talks that outline what we know, what needs to be done both empirically and with regards to theory, and highlight the untapped potential of overlapping research interests across disparate fields. We hope that this workshop will form the foundation for an ongoing collaboration between subdisciplines to tackle this urgent and interesting problem. As a first step, we will focus principally on unicells in the hope that they avoid some of the interesting but challenging complications of understanding cell size in multicellular organisms.

ECRs* interested in the causes and consequences of changes in cells size are invited to apply to attend this meeting.

*Defined as PhD, postdocs and PIs in the first three years of their first appointment.

 

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