Mitosis and Nuclear Structure
Organisers: Katherine Wilson, Timothy Mitchison and Michael Rout
Date: 23rd – 26th June 2013
Location: Wiston House, Steyning, West Sussex, UK
Mitosis and genome segregation in eukaryotes are surprisingly dependent on nuclear pore complex proteins (‘Nups’) plus actin and other components of the nucleoskeleton. This suggests nuclear structure and mitosis might have co-evolved in early eukaryotes. Fundamentally new insight about mitosis is also coming from bacteria, in which DNA segregation is mediated by proteins related to actin or other conserved nucleo-cytoskeletal proteins, and membrane-associated proteins. This high-level workshop brought together scientists who normally inhabit separate ‘worlds’— evolution, bacterial cell biology, eukaryotic mitosis, chromosome biology, and nuclear structure— for intensive discussions in the setting of a beautiful English estate to gain fresh insight, stimulate new ideas and forge innovative collaborations essential to understanding the conserved origins of life on earth.
Topics included;
Nuclear pore complexes and evolution
Nups and lamina proteins in mitosis
Mitotic spindle and ‘matrix’
Conserved nuclear membrane proteins
DNA partitioning in bacteria
Chromosomes in mitosis
Download programme for this Workshop
Published Information from the Workshop
Meeting report written by John C. Meadows, Katja Graumann, Melpi Platani, Nina Schweizer, Takeshi Shimi, Paola Vagnarelli, Jay C. Gatlin and published in the Journal of Cell Science.
JCS Reviews Editor Petra Gross interviews Katherine Wilson, Sir Tim Hunt and Ralph Gräf at the Workshop.
Organisers & Speakers
Timothy Michison Harvard University, Boston, USA
Michael Rout Rockefeller University, New York, USA
Catherine Dargemont INRS & Univ. Denis Diderot, Paris, France
Mary Dasso INIH, Bethesda, USA
Damien Devos Ruprecht-Karls-University, Heidelberg, Germany
Valerie Doye University of Paris, France
David Evans Oxford Brookes University, UK
Mark Field University of Cambridge, UK
Ralph Graf University of Potsdam, Germany
Yosef Gruenbaum The Hebrew University of Jerusalem, Israel
Rebecca Heard University of California, Berkeley, USA
Martin Hetzer The Salk Institute for Biological Studies, California, USA
Christine Jacobs-Wagner Yale University, USA
Kristen Johansen Iowa State University, USA
Tom Misteli NIH, Bethesda, USA
Eric Schirmer University of Edinburgh, Scotland, UK
David Sherratt University of Oxford, UK
Yixian Zheng Carnegie Institution for Science, Baltimore, USA
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